KMID : 0620920200520030010
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Experimental & Molecular Medicine 2020 Volume.52 No. 3 p.10 ~ p.10
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Potential therapeutic target for aging and age-related neurodegenerative diseases: the role of acid sphingomyelinase
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Park Min-Hee
Jin Hee-Kyung Bae Jae-Sung
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Abstract
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Aging, which is associated with age-related changes in physiological processes, is the most significant risk factor for the development and progression of neurodegenerative diseases, including Alzheimer¡¯s disease and Parkinson¡¯s disease. Accumulating evidence has indicated that sphingolipids are significant regulators that are associated with pathogenesis in aging and several age-related neurodegenerative diseases. In particular, abnormal levels of acid sphingomyelinase (ASM), one of the significant sphingolipid-metabolizing enzymes, have been found in the blood and some tissues under various neuropathological conditions. Moreover, recent studies have reported the importance of ASM as a critical mediator that contributes to pathologies in aging and age-related neurodegenerative diseases. In this review, we describe the pathophysiological processes that are regulated by ASM, focusing on the age-related neurodegenerative environment. Furthermore, we discuss novel insights into how new therapeutics targeting ASM may potentially lead to effective strategies to combat aging and age-related neurodegenerative diseases.
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KEYWORD
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Blood?brain barrier, Diseases of the nervous system
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